Product Description

PLCB4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10734-50, ES10734-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: PLCB4

Specificity: PLCB4 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Preferentially expressed in the retina,

Observed Band (KD): 129kD

Fields: Inositol phosphate metabolism, Metabolic pathways, Rap1 signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Chemokine signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Wnt signaling pathway, Apelin signaling pathway, Gap junction, Platelet activation, Neutrophil extracellular trap formation, NOD-like receptor signaling pathway, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Long-term depression, Taste transduction, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Glucagon signaling p

Function: Alternative Products: Additional isoforms seem to exist,Catalytic Activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactor: Calcium
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction
Similarity: Contains 1 C2 domain
Similarity: Contains 1 PI-PLC X-box domain
Similarity: Contains 1 PI-PLC Y-box domain
Tissue Specificity: Preferentially expressed in the retina

Subcellular Location: intracellular, nucleus, smooth endoplasmic reticulum, cytosol, postsynaptic density, dendrite,

Storage and Stability: -20°C/1 year

Gene Name: PLCB4

Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)

Rat SwissProt Number: Q9QW07

Research Use Only