Product Description

PLCE1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34132-50, RA34132-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: phospholipase C epsilon 1 (PLCE1) Homo sapiens This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4, 5-bisphosphate to generate two second messengers: inositol 1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IHC-p, IF (paraffin section)

Clonality: Polyclonal

Dilution: IHC-p 1:50-300

Molecular Weight: 253

Protein Molecular Weight (kDa): 253

Storage: -20°C/1 year

Human Gene ID: 51196

Human SwissProt Number: Q9P212

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only