PLEC Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA34135-50, RA34135-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: plectin (PLEC) Homo sapiens Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or &qu Reactivity: Human, Rat, Mouse Host: Rabbit Applications: IHC-p, IF (paraffin section) Clonality: Polyclonal Dilution: IHC-p 1:50-300 Molecular Weight: 515 Protein Molecular Weight (kDa): 515 Storage: -20°C/1 year Human Gene ID: 5339 Human SwissProt Number: Q15149 Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Research Use Only