PLOD2 Polyclonal Antibody - BT-AP13181

PLOD2 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13181-20, BT-AP13181-50, BT-AP13181-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Areas: Cancer; Metabolism; Signal transduction

Target Protein: PLOD2

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O00469; Mouse: Q9R0B9; Rat: Q811A3

Synonyms: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2;EC 1.14.11.4;Lysyl hydroxylase 2;LH2

GeneID: Human: 5352

Research Use Only