Product Description

PLXB1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34155-50, RA34155-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: disease:Overexpressed and constitutively tyrosine phosphorylated in colon, liver, pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth., function:Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration., PTM:Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding., PTM:Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding., similarity:Belongs to the plexin family., similarity:Contains 1 Sema domain., similarity:Contains 3 IPT/TIG domains., subunit:Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Binds ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2., tissue specificity:Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 234

Protein Molecular Weight (kDa): 234

Storage: -20°C/1 year

Human Gene ID: 5364

Human SwissProt Number: O43157

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only