PMEL Monoclonal Antibody - BT-MCA2732

PMEL Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2732-50, BT-MCA2732-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Research Areas: Others

Target Protein: PMEL

Applications: FCM

Clonality: Monoclonal

Clone ID: 1D4A5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: PMEL

Immunogen: Purified recombinant fragment of human PMEL (AA: 25-192) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 70.2kDa

UniProt Accession: P40967

Synonyms: P1, SI, SIL, ME20, P100, SILV, ME20M, gp100, ME20-M, PMEL17, D12S53E

GeneID: 6490

Research Use Only