PMS2 Monoclonal Antibody - BT-MCA4574

PMS2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4574-50, BT-MCA4574-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: PMS2

Applications: WB, FCM

Clonality: Monoclonal

Clone ID: 5A7F2

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: PMS2

Immunogen: Purified recombinant fragment of human PMS2 (AA: 748-851) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 95.8kDa

UniProt Accession: P54278

Synonyms: MLH4, PMSL2, HNPCC4, PMS2CL

GeneID: 5395

Research Use Only