Product Description

POLH Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34178-50, RA34178-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: DNA polymerase eta (POLH) Homo sapiens This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 78

Protein Molecular Weight (kDa): 78

Storage: -20°C/1 year

Human Gene ID: 5429

Human SwissProt Number: Q9Y253

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only