PORIM Polyclonal Antibody - BT-AP13230

PORIM Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13230-20, BT-AP13230-50, BT-AP13230-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.

Research Areas: Cell biology; Tags and cell markers; Metabolism; Cancer; Signal transduction

Target Protein: TMEM123

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Porimin

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q8N131; Mouse: Q91Z22; Rat: Q5HZB0

Synonyms: Porimin;Keratinocytes-associated transmembrane protein 3;KCT-3;Pro-oncosis receptor inducing membrane injury;Transmembrane protein 123

GeneID: Human: 114908

Research Use Only