Product Description

PP1C alpha Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB12341-50, MB12341-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Protein phosphatase that associates with over 200 regμlatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regμlation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regμlation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodμlin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regμlates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regμlator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regμlation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regμlatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).

Category: Primary Antibody

Reactivity: Human, Mouse, Monkey, Rat

Host: Mouse

Applications: WB, ICC/IF

Alternate Names: Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit, Catalytic subunit, PP1A, PP1A_HUMAN, PP1alpha, PP2C ALPHA, PP2CA, Ppp1ca, Protein Phosphatase 2C Alpha Isoform, Serine threonine protein phosphatase PP1 alpha catalytic subunit, Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit.

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Purified recombinant human PPP1A protein fragments expressed in E.coli.

Dilution: WB: 1/500-1/1000 IF: 1/50-1/200

Purification: Affinity Purified

Specificity: IgG1

Molecular Weight: Calcμlated MW: 38 kDa, Observed MW: 38 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P62136

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only