Product Description

PP2Cε Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4910-50, ES4910-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: PPM1L, PP2CE, Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon, PP2C-epsilon

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human PPM1L. AA range:119-168

Isotype: IgG

Target: PP2Cε

Specificity: PP2Cε Polyclonal Antibody detects endogenous levels of PP2Cε protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous, Highly expressed in heart, placenta, lung, liver, kidney and pancreas,

Observed Band (KD): 48kD

Function: Catalytic Activity: A phosphoprotein + H(2)O = a protein + phosphate
Cofactor: Binds 2 magnesium or manganese ions per subunit
Function: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6
Similarity: Belongs to the PP2C family
Similarity: Contains 1 PP2C-like domain
Subunit: Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5
Tissue Specificity: Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: PPM1L

Protein Name: Protein phosphatase 1L

Mouse Gene ID: 242083

Mouse SwissProt Number: Q8BHN0

Research Use Only