PREP Polyclonal Antibody - BT-AP13296

PREP Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13296-20, BT-AP13296-50, BT-AP13296-100

Citations, Manuals and MSDS Available upon request.

Background: cofactor:Binds 1 zinc ion per subunit.,ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.,PTM:The disulfide bond may lock the enzyme in a closed conformation under oxidized conditions, suggesting that it may participate in redox regulation of the enzyme.,Belongs to the peptidase M16 family. PreP subfamily.,subunit:Homodimer.,tissue specificity:Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.,

Research Areas: Cell biology

Target Protein: PITRM1

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Presequence protease, mitochondrial

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q5JRX3; Mouse: Q8K411

Synonyms: Presequence protease, mitochondrial;hPreP;EC 3.4.24.-;Pitrilysin metalloproteinase 1;Metalloprotease 1;hMP1

GeneID: Human: 10531

Research Use Only