PRF1 Monoclonal Antibody - BT-MCA2349

PRF1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2349-50, BT-MCA2349-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.

Research Areas: Others

Target Protein: PRF1

Applications: FCM

Clonality: Monoclonal

Clone ID: 6F8C2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: PRF1

Immunogen: Purified recombinant fragment of human PRF1 (AA: extra 148-372) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 61.3kDa

UniProt Accession: P14222

Synonyms: P1, PFP, HPLH2

GeneID: 5551

Research Use Only