Product Description

Progesterone Receptor Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66216-50, MB66216-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Human progesterone receptor (PR) is expressed as two forms: the fμll length PR-B and the short form PR-A. PR-A lacks the first 164 amino acid residues of PR-B (1, 2). Both PR-A and PR-B are ligand activated, but differ in their relative ability to activate target gene transcription (3, 4). The activity of PR is regμlated by phosphorylation, at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102, and Ser162) are unique to fμll length PR-B, while other sites (Ser190, Ser294, Ser345, and Ser400) are shared by both isoforms . Phosphorylation of PR-B at Ser190 (equivalent to Ser26 of PR-A) is catalyzed by CDK2 . Mutation of Ser190 resμlts in decreased activity of PR , suggesting that the phosphorylation at Ser190 may be critical to its biological function.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: IHC

Alternate Names: NR3C3, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Progesterone Receptor. The exact sequence is proprietary.

Dilution: IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Progesterone Receptor protein.

Molecular Weight: ~ 98 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P06401

Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only