PTEN Monoclonal Antibody - BT-MCA4500

PTEN Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4500-50, BT-MCA4500-100

Citations, Manuals and MSDS Available upon request.

Background: PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Research Areas: Cell Biology

Target Protein: PTEN

Applications: WB, ICC, FCM

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 1B8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: PTEN

Immunogen: Purified recombinant fragment of PTEN expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 54kDa

UniProt Accession: P60484

Synonyms: BZS, MHAM, TEP1, PTEN1

GeneID: 5728

Research Use Only