Product Description

PTN13 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34283-50, RA34283-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: protein tyrosine phosphatase, non-receptor type 13 (PTPN13) Homo sapiens The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, ha

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IHC-p, IF (paraffin section)

Clonality: Polyclonal

Dilution: IHC-p 1:50-300

Molecular Weight: 273

Protein Molecular Weight (kDa): 273

Storage: -20°C/1 year

Human Gene ID: 5783

Human SwissProt Number: Q12923

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only