Product Description

PTPα (phospho Tyr798) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6938-50, ES6938-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: PTPRA, PTPA, PTPRL2, Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human PTPRA around the phosphorylation site of Tyr798. AA range:753-802

Isotype: IgG

Target: PTPα

Specificity: Phospho-PTPα (Y798) Polyclonal Antibody detects endogenous levels of PTPα protein only when phosphorylated at Y798.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Epithelium, Kidney, Lymph node, Skin,

Observed Band (KD): 100 90kD

Function: Catalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily
Similarity: Contains 2 tyrosine-protein phosphatase domains

Subcellular Location: Cell membrane, Single-pass type I membrane protein Cell junction, focal adhesion Localizes to focal adhesion sites following integrin engagement

Storage and Stability: -20°C/1 year

Gene Name: PTPRA

Protein Name: Receptor-type tyrosine-protein phosphatase alpha

Mouse Gene ID: 19262

Mouse SwissProt Number: P18052

Rat SwissProt Number: Q03348

Research Use Only