PTPA Polyclonal Antibody - BT-AP13392

PTPA Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13392-20, BT-AP13392-50, BT-AP13392-100

Citations, Manuals and MSDS Available upon request.

Background: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, Bandapos;/PR61, and Bandapos;andapos;/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the Bandapos; family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Areas: Signal transduction

Target Protein: PPP2R4

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Serine/threonine-protein phosphatase 2A activator

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q15257; Mouse: P58389

Synonyms: Serine/threonine-protein phosphatase 2A activator;EC 5.2.1.8;PP2A, subunit B', PR53 isoform;Phosphotyrosyl phosphatase activator;PTPA;Serine/threonine-protein phosphatase 2A regulatory subuni

GeneID: Human: 5524

Research Use Only