PTPRM Monoclonal Antibody - BT-MCA2744

PTPRM Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2744-50, BT-MCA2744-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.

Research Areas: Signal transduction

Target Protein: PTPRM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1H6D10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: PTPRM

Immunogen: Purified recombinant fragment of human PTPRM (AA: extra 565-742) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 163.7kDa

UniProt Accession: P28827

Synonyms: RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU

GeneID: 5797

Research Use Only