PTRF Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA34303-50, RA34303-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: polymerase I and transcript release factor (PTRF) Homo sapiens This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrop Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, ELISA Clonality: Polyclonal Dilution: WB 1:500-2000 ELISA 1:5000-20000 Molecular Weight: 42 Protein Molecular Weight (kDa): 42 Storage: -20°C/1 year Human Gene ID: 284119 Human SwissProt Number: Q6NZI2 Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Research Use Only