PZP Polyclonal Antibody - BT-AP13427

PZP Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13427-20, BT-AP13427-50, BT-AP13427-100

Citations, Manuals and MSDS Available upon request.

Background: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.,Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.,subunit:Homotetramer, which consists of two pairs of disulfide-linked chains.,tissue specificity:Plasma. Prominent constituent of late-pregnancy sera.,

Research Areas: Neuroscience; Immunology

Target Protein: PZP

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Pregnancy zone protein

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P20742

Synonyms: Pregnancy zone protein;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

Research Use Only