Product Description

R Cadherin Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67470-50, BS67470-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellμlar domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development . The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellμlar structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton . While β- and γ-catenin play structural roles in the junctional complex, p120 regμlates cadherin adhesive activity and trafficking ). Investigators consider E-cadherin an active suppressor of invasion and growth of many epithelial cancers ). Research studies indicate that cancer cells have upregμlated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch." N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellμlar invasion . Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascμlar permeability and tumor angiogenesis . Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: Cadherin-4, Retinal cadherin, R-CAD, R-cadherin

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human R Cadherin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of R Cadherin protein.

Molecular Weight: ~ 130 kDa

Pathway: Wntβ catenin signaling，ErbB HER Signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P55283

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only