R-Spondin Monoclonal Antibody - BT-MCA1079

R-Spondin Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1079-50, BT-MCA1079-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.

Research Areas: Stem Cells; Developmental Biology

Target Protein: RSPO1

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: R-spondin-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q2MKA7; Mouse: Q9Z132

Synonyms: RSPO1; R-spondin-1; Roof plate-specific spondin-1; hRspo1

GeneID: Human: 284654

Research Use Only