Raf-B Monoclonal Antibody - BT-MCA1088

Raf-B Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1088-50, BT-MCA1088-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Research Areas: Signal transduction; Cancer; Cell biology

Target Protein: BRAF

Applications: WB, IHC-p, IF, ICC, ELISA

Reactivity: Human,Mouse

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Serine,threonine-protein kinase B-raf

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P15056; Mouse: P28028

Synonyms: BRAF; BRAF1; RAFB1; Serine; threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1

GeneID: Human: 673; Mouse: 109880

Research Use Only