RAF1 Monoclonal Antibody - BT-MCA2994

RAF1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2994-50, BT-MCA2994-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Research Areas: Signal Transduction

Target Protein: RAF1

Applications: WB, IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 4G4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: RAF1

Immunogen: Purified recombinant fragment of human RAF1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

UniProt Accession: P04049

Synonyms: NS5, CRAF, Raf-1, c-Raf

GeneID: 5894

Research Use Only