RAG2 Monoclonal Antibody - BT-MCA3435

RAG2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3435-50, BT-MCA3435-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Research Areas: Epigenetics and nuclear signaling

Target Protein: RAG2

Reactivity: Human

Clonality: Monoclonal

Clone ID: 4D5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: RAG2

Immunogen: Purified recombinant fragment of human RAG2(350-527aa) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 59kDa

UniProt Accession: P55895

Synonyms: RAG-2, RAG2

GeneID: 5897

Research Use Only