RAGE (Q286) Polyclonal Antibody-BS2165

RAGE (Q286) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2165-50, BS2165-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UQ07

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFκB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 Ras and MAP kinase, which leads to activation of transcription.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of RAGE (Q286) pAb in paraffin-embedded human tonsil cancer tissue at 1:50.

Bioworld Molecular Weight: ~ 48 kDa

Specificity: RAGE (Q286) polyclonal antibody detects endogenous levels of RAGE protein.

Alternative Name: MAPK/MAK/MRK overlapping kinase; MOK protein kinase; Renal tumor antigen 1; Renal tumor antigen 1; Renal tumor antigen 1; RAGE; RAGE1

Immunogen: Synthetic peptide, corresponding to amino acids 254-308 of Human RAGE.

Conjugate: Unconjugated

Modification: Unmodified