Product Description

RALA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10925-50, ES10925-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: RAS like proto-oncogene A(RALA) Homo sapiens The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: RALA

Specificity: RALA Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Eye, Lung, Platelet,

Observed Band (KD): 22kD

Fields: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, Salmonella infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer

Function: Similarity: Belongs to the small GTPase superfamily. Ras family
Subunit: Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1

Subcellular Location: Cell membrane, Lipid-anchor, Cytoplasmic side Cleavage furrow Midbody, Midbody ring Mitochondrion Predominantly at the cell surface in the absence of LPA In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925) May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214) However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269) Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277)

Storage and Stability: -20°C/1 year

Gene Name: RALA RAL

Protein Name: Ras-related protein Ral-A

Mouse SwissProt Number: P63321

Rat SwissProt Number: P63322

Research Use Only