Product Description

RANG Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10092-50, ES10092-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 30-110

Isotype: IgG

Target: RANG

Specificity: RANG Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Blood,

Observed Band (KD): 22kD

Fields: Human T-cell leukemia virus 1 infection, Viral carcinogenesis

Function: Function: Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane
Similarity: Belongs to the RANBP1 family
Similarity: Contains 1 RanBD1 domain

Subcellular Location: intracellular, nucleus, nuclear envelope, cytoplasm, centrosome, cell-cell adherens junction, axon cytoplasm,

Storage and Stability: -20°C/1 year

Gene Name: RANBP1

Protein Name: Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)

Mouse SwissProt Number: P34022

Research Use Only