RAP1GAP Monoclonal Antibody - BT-MCA3461

RAP1GAP Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3461-50, BT-MCA3461-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Research Areas: Signal Transduction

Target Protein: RAP1GAP

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2G7B6

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: RAP1GAP

Immunogen: Purified recombinant fragment of human RAP1GAP (AA: 412-660) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide.

Molecular Weight (Da): 73.4kDa

UniProt Accession: P47736

Synonyms: RAPGAP, RAP1GA1, RAP1GAP1, RAP1GAPII

GeneID: 5909

Research Use Only