RASSF1 Monoclonal Antibody - BT-MCA1093

RASSF1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1093-50, BT-MCA1093-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Research Areas: Signal transduction; Cancer; Cell biology; Epigenetics and nuclear signaling

Target Protein: RASSF1

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Ras association domain-containing protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9NS23; Mouse: Q99MK9

Synonyms: RASSF1; RDA32; Ras association domain-containing protein 1

GeneID: Human: 11186

Research Use Only