Rb Monoclonal Antibody - BT-MCA1094

Rb Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1094-50, BT-MCA1094-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Research Areas: Cancer; Cell biology; Epigenetics and nuclear signaling

Target Protein: RB1

Applications: IHC-p, IF, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Retinoblastoma-associated protein

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P06400; Mouse: P13405

Synonyms: RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

GeneID: Human: 5925

Research Use Only