RB Monoclonal Antibody - BT-MCA2508

RB Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2508-50, BT-MCA2508-100

Citations, Manuals and MSDS Available upon request.

Background: The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).

Research Areas: Others

Target Protein: RB

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7E4B8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: RB

Immunogen: Purified recombinant fragment of human RB expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P06400

Synonyms: RB, pRb, OSRC, pp110, p105-Rb, RB1

GeneID: 5925

Research Use Only