Product Description

RBBP6 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10156-50, ES10156-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein . at AA range: 270-350

Isotype: IgG

Target: RBBP6,

Specificity: RBBP6 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.

Observed Band (KD): 197kD

Function: PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. sequence Caution: Contaminating sequence. Potential poly-A sequence. sequence Caution: Intron retention. Similarity: Contains 1 CCHC-type zinc finger. Similarity: Contains 1 DWNN domain. Similarity: Contains 1 RING-type zinc finger. Subcellular Location: Colocalizes with mitotic chromosomes. Subunit: Interacts with p53/TP53 and RB1. Tissue Specificity: Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.

Subcellular Location: Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.

Storage and Stability: -20°C/1 year

Gene Name: RBBP6, P2PR, PACT, RBQ1, My038

Protein Name: E3 ubiquitin-protein ligase RBBP6, EC 6.3.2.-, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, RBQ-1, Retinoblastoma-binding protein 6, p53-associated

Human Gene ID: 5930

Human SwissProt Number: Q7Z6E9

Mouse SwissProt Number: P97868

Research Use Only