Product Description

Rbx1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67050-50, MB67050-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: RING-box protein 1 (RBX1 or ROC1) is an essential component of two distinct but structurally related E3 ubiquitin ligase complexes, the SCF complex and the CBC (VHL) complex . RBX1 mediates the neddylation of Cμl1, which activates SCF E3 ligase by facilitating the ubiquitin transfer from E2 to substrates . The RING finger domain of RBX1 is required for ubiquitin ligation . Two evolutionarily conserved mammalian RBX family members, RBX1/ROC1 and RBX2/ROC2/SAG, have been identified . RBX1 is constitutively expressed and binds to Cμl2/VHL, while stress-inducible RBX2 binds to Cμl5/SOCS .

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Mouse

Applications: WB

Alternate Names: RNF75, ROC1, E3 ubiquitin-protein ligase RBX1, Protein ZYP, RING finger protein 75, RING-box protein 1, Rbx1, Regμlator of cμllins 1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human Rbx1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Rbx1 protein.

Molecular Weight: ~ 13 kDa

Pathway: Tumor Angiogenesis.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P62877

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only