Recombinant Human IL-29 Protein
Sizes: 20μg, 100μg
Catalogue Numbers: PDMH100027-20, PDMH100027-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: IL-29
Target Synonym: Interferon lambda-1; IFN-lambda-1; ytokine Zcyto21; Interleukin-29; IL29; IFNL1; ZCYTO21
UNIProt ID: Q8IU54
Research Areas: Cancer; Cardiovascular; Immunology;
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: N-10His
Accession: Q8IU54
Background: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Sequence: Met1-Thr200
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4., 5% trehalose, 5% mannitol, 0.01% tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 22 kDa
Observed MW: 28-35 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only