Recombinant Human KIM-1(C-6His)
Size: 1mg
Catalogue Number: PKSH033813-1
Citations, Manuals and MSDS Available upon request.
Abbreviation: KIM-1
Target Synonym: HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, Hepatitis A virus
cellular receptor 1
UNIProt ID: F1CME6
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-6His
Accession: F1CME6
Background: Kidney injury molecule-1 (KIM-1) (also known as TIM-1 and HAVCR) is a type 1 transmembrane glycoprotein found on activated CD4+ T cells, especially Th2 cells, and dedifferentiated proximal tubule epithelial cells. In humans, KIM-1 levels are very low or undetectable in normal samples, but following drug toxicity or ischemic damage to the kidney, the 85 kD, mucin-rich extracellular region of this molecule is shed and detected at elevated levels in urine, serum, and plasma. Therefore, KIM-1 is a suitable renal biomarker capable of early detection and progressive monitoring of acute kidney injury beyond traditional injury markers such as serum creatinine (SCr) and blood urea nitrogen (BUN) which lack specificity and sensitivity. KIM-1 has also been implicated in the development of atopic airway disease (asthma) and Th2-biased autoimmune responses.
Sequence: Ser21-Gly290
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μM filtered solution of PBS, pH7.4, 5% Trehalose
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Not Applicable
Endotoxin: Please contact us for more information.
Calculated MW: 29.8 kDa
Observed MW: 80-120 kDa
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Research Use Only