Ref-1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29327-50, RA29327-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) Homo sapiens Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008], Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, ELISA Alternate Names: APEX1, APE, APE1, APEX, APX, HAP1, REF1, DNA- (apurinic or apyrimidinic site) lyase, APEX nuclease, APEN, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1, REF-1, Redox factor-1 Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. Storage: -20°C/1 year Human Gene ID: 328 Human SwissProt Number: P27695 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only