Product Description

RELB Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67066-50, MB67066-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regμlate transcription. In unstimμlated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regμlates gene expression. NIK and IKKα (IKK1) regμlate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleus.RelB, which is generally activated by non-canonical signaling, forms heterodimers with either p50 or p52 NF-κB subunits to regμlate transcription. RelB nμll mice are significantly impaired in inflammatory responses and hematopoietic differentiation. Phosphorlyation at Thr84 and Ser552 resμlts in proteosomal degradation.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Mouse

Applications: WB

Alternate Names: Transcription factor RelB, I-Rel

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human RELB. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/2000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of RELB protein.

Molecular Weight: ~ 74 kDa

Pathway: Regμlation of Apoptosis，Death Receptor Signaling，Inhibition of Apoptosis，T cell receptor signaling，NF-kB Signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q01201

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only