RFA2 Monoclonal Antibody - BT-MCA2782

RFA2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2782-50, BT-MCA2782-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.

Research Areas: Others

Target Protein: RFA2

Applications: WB, IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2C5B6

Host: Mouse

Isotype: Mouse IgG1,kappa

Full Product Name: RFA2

Immunogen: Purified recombinant fragment of human RFA2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 29kDa

UniProt Accession: P15927

Synonyms: RP-A p34, RPA2, REPA2, RPA32, RPA34

GeneID: 6118

Research Use Only