Product Description

RGMA Rabbit Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS41370-50, BS41370-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Member of the repμlsive guidance molecμle (RGM) family that performs several functions in the developing and adμlt nervous system. Regμlates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Category: Primary Antibody

Reactivity: Human Mouse Rat

Host: Rabbit

Applications: WB, ICC/IF

Alternate Names: Repμlsive guidance molecμle A, RGM, RGM domain family member A, RGMA,

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: A synthesized peptide derived from human RGMA

Dilution: WB 1:500~1:2000 ICC/IF 1:50~1:200

Purification: Affinity-chromatography

Specificity: RGMA Antibody detects endogenous levels of total RGMA

Molecular Weight: 37kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96B86

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only