Product Description

RIPK3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10828-50, ES10828-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: RIP3,

Specificity: RIPK3 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. ; [Isoform 3]: Expression is significantly increased in colon and lung cancers.

Observed Band (KD): 56kD

Fields: Necroptosis, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, TNF signaling pathway, Salmonella infection

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein. Promotes apoptosis. PTM: Autophosphorylated. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Similarity: Contains 1 protein kinase domain. Subunit: Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. Tissue Specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

Subcellular Location: Cytoplasm, cytosol Nucleus Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection.

Storage and Stability: -20°C/1 year

Gene Name: RIPK3, RIP3

Protein Name: Receptor-interacting serine/threonine-protein kinase 3, EC 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3

Human Gene ID: 11035

Human SwissProt Number: Q9Y572

Mouse SwissProt Number: Q9QZL0

Rat SwissProt Number: Q9Z2P5

Research Use Only