ROCK1 Monoclonal Antibody - BT-MCA2623

ROCK1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2623-50, BT-MCA2623-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Research Areas: Signal Transduction

Target Protein: ROCK1

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1H4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ROCK1

Immunogen: Purified recombinant fragment of human ROCK1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 158kDa

UniProt Accession: Q13464

Synonyms: ROCK-I, PRO0435, MGC43611, P160ROCK, MGC131603

GeneID: 6093

Research Use Only