Product Description

ROR1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4049-50, BT-MCA4049-100

Citations, Manuals and MSDS Available upon request.

Background: ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.

Research Areas: Signal transduction, Neuroscience

Target Protein: ROR1

Applications: ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2H6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ROR1

Immunogen: Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 101kDa

UniProt Accession: Q01973

Synonyms: ROR1

GeneID: 4919

Research Use Only