RSK1 Monoclonal Antibody - BT-MCA2270

RSK1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2270-50, BT-MCA2270-100

Citations, Manuals and MSDS Available upon request.

Background: Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB. RSK proteins possess two separate kinase domains, the C terminal kinase domain and the N terminal kinase domain, separated by a linker region containing a hydrophobic motif. RSK is activated by many stimuli including growth factors, phorbol esters, cAMP, heat shock, and irradiation.

Research Areas: Others

Target Protein: RSK1

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 10B1D7A9

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: RSK1

Immunogen: Purified recombinant fragment of human RSK1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q15418

Synonyms: RSK, HU-1, RSK1, MAPKAPK1A, RPS6KA1

GeneID: 6195

Research Use Only