Rtn-3 Monoclonal Antibody - BT-MCA1109

Rtn-3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1109-50, BT-MCA1109-100

Citations, Manuals and MSDS Available upon request.

Background: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.

Research Areas: Cell Biology; Signal Transduction; Metabolism; Cancer

Target Protein: RTN3

Applications: IHC-p, IF, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Reticulon-3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O95197; Mouse: Q9ES97

Synonyms: RTN3; ASYIP; NSPL2; Reticulon-3; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII

GeneID: Human: 10313

Research Use Only