Product Description

RXFP1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11633-50, ES11633-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein . at AA range: 240-320

Isotype: IgG

Target: RXFP1,

Specificity: RXFP1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.

Observed Band (KD): 83kD

Fields: Neuroactive ligand-receptor interaction, Relaxin signaling pathway

Function: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Similarity: Belongs to the G-protein coupled receptor 1 family. Similarity: Contains 1 LDL-receptor class A domain. Similarity: Contains 10 LRR (leucine-rich) repeats. Tissue Specificity: Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.

Subcellular Location: Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: RXFP1, LGR7

Protein Name: Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1

Human Gene ID: 59350

Human SwissProt Number: Q9HBX9

Mouse SwissProt Number: Q6R6I7

Rat SwissProt Number: Q6R6I6

Research Use Only