Product Description

S10A2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10064-50, ES10064-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: S100 calcium binding protein A2(S100A2) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 40-120

Isotype: IgG

Target: S10A2

Specificity: S10A2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes,

Observed Band (KD): 10kD

Function: Developmental Stage: Preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones. The level of S100L was shown to correlate inversely with tumor progression
Function: May act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. May also play a role in suppressing tumor cell growth
Induction: By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells
Miscellaneous: This protein binds two calcium ions
Similarity: Belongs to the S-100 family
Similarity: Contains 2 EF-hand domains
Tissue Specificity: A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes

Storage and Stability: -20°C/1 year

Gene Name: S100A2 S100L

Protein Name: Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)

Research Use Only