SACS Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA34721-50, RA34721-100 Citations, Manuals and MSDS Available upon request. Background: sacsin molecular chaperone (SACS) Homo sapiens This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651) . Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IHC-p 1:50-300 Applications: IHC-p; IF (paraffin section) Species Cross-Reactivity: Human; Mouse GeneID (Human): 26278 Protein MW (KDa): 503 SWISS: Q9NZJ4 Source: Rabbit Research Use Only