Product Description

SC5A5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10287-50, ES10287-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: SC5A5,

Specificity: SC5A5 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.

Observed Band (KD): 70kD

Fields: Thyroid hormone synthesis

Function: Disease: Defects in SLC5A5 are the cause of congenital hypothyroidism due to dyshormonogenesis type 1 (CHDH1) [MIM:274400]. CHDH1 is characterized by an inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Mediates iodide uptake in the thyroid gland. Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Tissue Specificity: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.

Subcellular Location: Membrane, Multi-pass membrane protein.

Storage and Stability: -20°C/1 year

Gene Name: SLC5A5, NIS

Protein Name: Sodium/iodide cotransporter, Na(+ /I(- cotransporter, Sodium-iodide symporter, Na(+ /I(- symporter, Solute carrier family 5 member 5

Human Gene ID: 6528

Human SwissProt Number: Q92911

Mouse SwissProt Number: Q99PN0

Rat SwissProt Number: Q63008

Research Use Only